Orlistat for Weight Loss

Orlistat is a drug that is typically prescribed to treat obesity. It works by blocking some of the fat in your diet and prevents it from being absorbed by the body. It is also used to help you keep off weight that you may have already lost.

Orlistat weight loss drug - 120 mg strength
Orlistat 120 mg

Traditionally, Orlistat was only available by prescription. In 2007, the FDA approved Orlistat for over-the-counter sales. It was the first FDA approved weight loss product to hit the U.S. consumer market. It is sold over-the-counter at half of the prescription dose. Roche manufactures the prescription strength formula under the name Xenical.  The over-the-counter formula is sold under the trade name Alli.

How Orlistat works?

Orlistat is a lipase inhibitor that works by preventing fat absorption in the diet, thereby reducing caloric intake. It is typically prescribed by physicians to be used in conjunction with a supervised reduced-calorie diet and exercise program. Orlistat works by preventing triglycerides from being broken down in the intestines. In inhibits gastric and pancreatic lipases or enzymes from breaking down the triglycerides. Unprocessed fat and triglycerides are excreted from the body without being altered.

Orlistat Dosage

Prescription strength of this drug is 120 mg, taken three times a day prior to eating. At this dose about 30% of dietary fat is blocked from being absorbed. The over-the-counter dose is 60 mg which blocks about 25% of dietary fat from being absorbed. Higher doses have not been shown to have any additional fat absorption abilities. It should never be given to a child under the age of 12. It is not recommended for anyone under the age of 18.


Orlistat has proven effective at moderately reducing weight loss. Clinical trials suggest that taken in addition to diet and exercise can reduce weight by 4-6 pounds more per year than those not taking the medication. It’s effectiveness at reducing body fat varies from person to person. In one year clinical trials, 16-24% of people taking this medicine achieved a decrease in body fat of more than 10%. Another 35-54% of individuals achieved at least a 5% decrease in body mass. It has been shown to reduce the chances of developing type 2 diabetes and has been linked to a reduction in blood pressure. It is unclear if these decreases are due to Orlistat or due to the lifestyle changes that come along with a low fat diet and a long-term exercise plan.

Counterfeit Orlistat on the internet

In 2010, the FDA issued a warning that counterfeit Orlistat was being sold on the internet under the Alli label. This product was found to contain a different weight loss drug, Sibutramine. The concentration of this drug was over twice the recommended safe dose for weight-loss. They warned consumers that they should not purchase Orlistat or Alli online.


Orlistat has been shown to inhibit the absorption of fat-soluble vitamins and some fat-soluble nutrients. A vitamin supplement containing beta-carotene and vitamins A, D, E, and K should be taken once a day, at bedtime, while taking this medication. It should not be taken with certain other medications. It has a potential to reduce plasma levels of Ciclosporin which is an immune suppressant that is used frequently to prevent transplant rejection. Some research indicates that it may also reduce the effectiveness of some antiviral HIV medications. If you are taking any of these medications you should not begin taking this medicine. If you are currently taking Orlistat and you have been prescribed medication for one of these serious conditions you should discontinue using Orlistat. It should not be taken in conjunction with any other weight-loss products.

Side Effects of Orlistat

Orlistat does not have many side effects, but the ones it does have can provide severe discomfort to users. It works, in part, by using aversion therapy. Most consumers suffer from side effects when they begin treatment using this medication. Most side effects are gastrointestinal-related. They include loose oily stools and increased flatulence. Fecal incontinence and frequent and urgent bowel movements are often reported by users. This is due to unabsorbed fats entering the large intestine. It is designed to cause these effects in order to get users to reduce the fat content in their meals. The manufacturer recommends that consumers adopt a low-fat, reduced calorie diet while taking ths medicine. When dietary fat is reduced to below 15 grams per meal, the symptoms are much less severe. Alli clearly states on its packaging information that Olistat works by using this aversion therapy. Side effects are worse when first beginning treatment and decrease over time. It is believed that long-term dietary changes may have more to do with improved symptoms than adaptation to Orlistat does.

In 2010 the FDA approved a label revision stating that severe liver injury can be a side effect of using Orlistat. It is rare, but has been reported by individuals taking the prescription dose of the medication. A 2013 study of 94,695 Olistat consumers was published by the British Medical Journal. They did not find any evidence to support a higher incidence of liver damage associated with the product.

In a study which included 900 Orlistat users, the rate of acute kidney injury was more than triple that of those not taking the medication. The mechanism responsible for those these results may be due to an excessive oxalate absorption rate by the gut. This oxalate is then deposited in the kidneys, causing a buildup and subsequent kidney injury.


You should avoid taking Olistat if you have several conditions. You should use this product with caution if you suffer from obstructed bile ducts, impaired liver function or pancreatic disease. You should also avoid this product if you are under the age of 18. It should not be taken by individuals with type 1 or type 2 Diabetes, pancreatic disease, kidney problems, liver problems or those with under active thyroids. You should also avoid taking Orlistat if you are allergic to it or if you have had an allergic reaction to it in the past. You should not take this product if you suffer from Malnutrition or reduced gall bladder functioning. Orlistat should never be taken if you are pregnant or breastfeeding.

PhenTabz Review

It is an over-the-counter weight loss pill that is designed to aid in rapid weight loss while suppressing appetite and boosting metabolism. PhenTabz is one of the dietary supplements that has gained much popularity over the years in the market with the unique claim of being a former prescription-only weight loss pill that is now available without any prescription.

Looking at supplements, the company that created it refused to disclose lots of vital information about their company. The information given about the pill is inadequate, which does not make much sense.

Appetite suppressants work by curbing the urge for food and enable the body to burn excess carbs and fats while enhancing weight loss. It contains ingredients that reduce the urge for food. It also increases the metabolism, which increases the potential for fat burning. PhenTabz is a not so strong appetite suppressant compare to prescription diet pills.

The manufacturers claim the pill has two benefits in one. It suppresses the appetite so you will not have an urge for food and it also mobilizes fat while raising the metabolic rate. This may sound great, but the mobilization of fat cells does not have anything to do with weight loss as this fat is likely to just move into other cells in the body.

PhenTabz Manufacturers

PhenTabz was developed by Lexium International but introduced onto the market by Gentech Pharmaceuticals in 2001. Lexium international has been operating for over twenty-five years.


  • PhenTabz promises to boost energy levels and customer reviews seem to support this claim..
  • The over-the-counter version of PhenTabz works in two ways to shed excess weight; it curbs hunger and raises the body’s metabolism.
  • It is not unique, several other appetite suppressants claim to work in a similar manner.

PhenTabz Dosage

PhenTabz is taken twice a day, once before breakfast and once before lunch. It is preferable to take it with water instead of juice or coffee.


  • The major concern with this supplement is the fact that there is no adequate information on its ingredients, which has made many people that are willing to try it out reluctant to make a purchase.
  • Some of its ingredients that have been listed are known to have been banned in many countries, like DMAA.

PhenTabz Ingredients

There are four disclosed ingredients associated with PhenTabz:


This includes caffeine and it is always amongst weight loss supplement ingredients because it is a good energy and metabolism booster. It can also aid in suppressing the appetite. Caffeine is typically used as a supporting ingredient because it enhances the effects of the other ingredients.


This is also known as Methylhexanamine and its included to help act as an additional appetite suppressant. It has been claimed that it is useful for suppressing the appetite for three to four hours. This is good in the sense that it will reduce the consumption of snacks that poses a hindrance to dieting programs. It has not been determined how DMAA may affect health in general. It was banned in many countries when it was linked to several deaths. It can cause high blood pressure, strokes, brain bleeding, and psychotic disorders.


The main active ingredient of Phentabz is found in a proprietary blend the manufacturer termed Ampheta-HCL. Ampheta-HCL is a proprietary list of ingredients that made this product seem to be very stable and act as an effective weight loss pill.


Octopamine has some known to aid in the release and mobilization of fat from fat cells. This fat that is released is usually absorbed by other fat cells immediately so you do not actually lose any weight, you just move the fat around. There is no clinical evidence as to how it can assist with weight loss, and combining it with stimulants like caffeine, it can have a significant effect on the blood pressure rate.


  • Due to some of its known ingredients that are good appetite suppressants, this can help to reduce food intake.
  • Phentabz are good metabolism boosters, which will provide you with additional energy to use in day to day activities.
  • PhenTabz does not require any change in its user’s lifestyle in order for it to work effectively for weight reduction.


  • One negative side effect that has been associated with the use of PhenTabz is sleeplessness.
  • Another side effect is dry mouth.
  • It is advisable to take the pill early in the morning and early afternoon to avoid sleeplessness.

Customer Reviews

This product really cleared up my thinking the first few times I used it, but after a few days this effect wore off and I did not see any other benefits from this product.

I really just wanted a diet pill that would help reduce my appetite, but this product did not help me at all. At first it made me feel a little more alert after I took it, but eventually that went away.

There is no useful information on the bottle to explain what this supplement contains. It also does not say how or where it was made.

This pill has not helped me cut back on my food intake. It made me very jittery the first two days that I took it. I felt excited. Now I don’t notice any effect from it at all.

2 Stars Reviews PhenTabz - Phentermine Alternative
2 stars - "I went to the site and tried to locate information about this drug. All I could find were marketing materials. It promised to not just make me feel less hungry, but it was supposed to help me burn fat too. This is not what happened. I did not notice any results after taking PhenTabz for a month." Based on 112,321 Votes since 2005!

Verdict – Rejected

This product cannot be recommended as a safe diet pill. There is very little information about the company that manufactured the product. The entire ingredient list has not been disclosed for this product. There are serious questions about the safety of some of the ingredients. Some of the ingredients in this product have been banned in some countries because they have been known to cause death. For all these reasons we reject this as a healthy weight loss alternative. Non-stimulant Conjugated Linoleic Acid supplement by Feel Spirit will give you better weight loss results.