What is Topiramate?

​Topiramate is an anticonvulsant and nerve pain prescription drug. It also, however, comes along with side effects resulting in weight loss. For this reason, it has been added as a prescription alongside phentermine for many people who are suffering with obesity.



​These two drugs are often prescribed to individuals whose health is at risk due to obesity and the comorbid disorders that often come along with it. However, they are not prescribed without a change in diet, exercise, and overall lifestyle. Phentermine helps to suppress appetite as an amphetamine. However, there still comes some intense cravings with the dietary changes that doctors prescribe. The individual who takes phentermine is to reduce their caloric intake over time. As the number of calories consumed per day drops, the individual can start to feel powerful cravings for more food. Topiramate helps to alleviate these cravings, making the weight loss process much easier and usually more successful.

​When an individual is obese, substantial weight loss is very important, because it improves the overall health of the individual and decreases the risk factors for heart disease, diabetes, high blood pressure, and premature death. This combination of Topiramate and Phentermine is often taken orally once a day, with or without food, but always as directed by your doctor. Dosage is based upon the condition of each individual and how they are responding to treatment. Doctors will often start small and build up to a proper level for each individual. Unless your doctor tells you otherwise, it is most often recommended that plenty of fluids are consumed while taking this medication. Aside from the dry mouth it can cause, it is recommended to avoid the occurrence of kidney stones.

​There is still question as to how Topiramate causes weight loss in individuals who are prescribed this medication. It could work as an actual appetite suppressant. It could work by increasing the body’s levels of energy used. It could increase metabolic rate, or it could produce a neurological effect that leads to the weight loss. Some other side effects of Topiramate when taken with phentermine include dry mouth, drowsiness, dizziness, difficulty sleeping, tiredness, paraesthesia (tingling in hands and feet), constipation, and a metallic taste in the mouth.

Of course, with any prescription medication, if an individual is experiencing these side effects persistently, they should check in with their physician or pharmacist. However, most people do not experience these adverse side effects, and if they do, it is often mild. Before taking Topiramate with Phentermine, an individual should notify their doctor of their medical history or any lifestyle risk factors such as:

  1. High blood pressure
  2. Glaucoma
  3. History of drug and/or alcohol abuse
  4. Heart disease (heart attack, chest pain, murmur, irregular heartbeat, and/or heart valve issues)
  5. Psychological mood disorders
  6. Pulmonary hypertension (high blood pressure in the lungs)
  7. Storke
  8. Hyperthyroidism
  9. Seizures
  10. Kidney or liver disease
  11. Metabolic acidosis (imbalance)
  12. Ketogenic diet (high fat, low carb)
  13. Pregnant, breastfeeding, or may become pregnant
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